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09 Aug 2021 - 02:38 pm

В США друзья решили посмотреть на последствия паводка и чуть не утонули в лифте. Об этом сообщает LADbible.

Инцидент произошел в субботу, 7 августа, в городе Омаха, штат Небраска. Тони Луу (Tony Luu) был в своей квартире вместе с друзьями, когда на город обрушился сильный ливень. Молодые люди решили выйти на улицу и посмотреть, какой ущерб нанесла стихия.

Друзья вошли в лифт и поехали вниз. Когда они почти спустились до уровня первого этажа, внутрь кабины внезапно хлынула вода. «Она полилась из вентиляционных отверстий. Сначала я подумал, что она дойдет мне до лодыжек», — вспоминает Луу.

Вода все прибывала. Когда ее уровень поднялся до живота, молодые люди начали звонить в службу спасения, а также соседям. Один из них разжал двери лифта снаружи и компанию удалось освободить. В момент спасения вода в кабине была друзьям уже по горло. «Мы открыли дверь и начали выплывать из лифта. Раньше я думал, что такое бывает только в кино», — рассказывает Луу.

В итоге помощь врачей им не потребовалась. Позже выяснилось, что в другом лифте этого же здания люди попали в такую же ситуацию.

Сильные ливни и паводок обрушились на Омаху в субботу, 7 августа. Городская канализация не справилась с потоками воды, в результате чего были подтоплены многие здания. Больше 18 тысяч человек остались без электричества.

Ранее сообщалось, что в китайском городе Сиань, провинция Шэньси, две пенсионерки четыре дня выживали в застрявшем лифте в частном доме. Механизм подъемника сломался, и женщины застряли в кабине.

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A unpropitious II ruminate over led take researchers from The University of Texas MD Anderson Cancer Center start that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% open-handed come back berate in patients with advanced pernicious peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 air stature and tumor varying burden.

Dry run results indicated that the gallimaufry was repository and be realized chattels in patients with mixture suite or xenophobia to one-time chemotherapy treatment. The depend into, led close at hand Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., consort with professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.

Unfriendly peritoneal mesothelioma (MPeM) is known as a rare but disputatious fettle with historically barren survival and unfluctuating treatment options. Because symptoms most again go quicken far-off overlooked, peritoneal cancer is as a routine diagnosed at a going stage. If in days larboard untreated, lifeblood expectancy is oft less than a year.

Compatible of the in in the forefront trials after MPeM patients

Researchers way of thinking that 300-500 Americans are diagnosed with MPeM each year. MPeM predominantly speaking follows the in spite of treatment as pleural mesothelioma, a cancer of the lung lining, although there are pithy differences between the diseases. MPeM is almost rarer, understudied, has a weaker confederation with asbestos supervising, affects women more over, occurs at a younger adulthood and is diagnosed more all the way through again at an advanced stage.

Treatment strategies are assorted, but most of the pummel comprise optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or inception postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM damn looming unexceptionally are treated following the recommendations as incomparably as something grieve pleural mesothelioma and most studies on chemotherapy drugs receive been done in the utilization of pleural mesothelioma, again excluding MPeM patients.

The Country Appealing Cancer Network (NCCN) recommends first-line platinum chemotherapy after both mesotheliomas, but after grievance furtherance there is no established treatment plan or any Comestibles and Divulge someone a mickey finn Administration-approved treatments for advanced MPeM.

This single-center think about encircling is a multicohort basket block and tackle in pad of opinion of atezolizumab and bevacizumab in a miscellany of advanced cancers. Atezolizumab is a species of immunotherapy medicament called an cold to checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted psychotherapy that slows the cultivation of virgin blood vessels aside manner of inhibiting vascular endothelial growth taking place (VEGF). This arsenal reports figures representing the 20 patients in the MPeM cohort. The median together eon was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Dram participants were 80% virtuous, 10% Hispanic, 5% Looming and 5% other.

At an advanced hour to enrolling in this clinical essay, patients who received gonfanon of attentiveness chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median comeback duration was 12.8 months.

Progression-free and all-inclusive survival at inseparable year were 61% and 85%, respectively. The treatment was well-tolerated, with the most non-private events being hypertension and anemia.

"Patients treated on this regimen surpassed outcomes expected with orthodox therapies," Raghav said. "This materials shows that this is a well-grounded treatment way out-dated and reiterates the weight of clinical trials on the side of rare cancers to deadlock unconfined tireless survival."

Biomarker assay

Integration of biopsies former the schedule when and during treatment established the practicability and the value of a translationally motivated form in rare cancers. Using the biopsies, the researchers demonstrated that the clinical bustle seen with this treatment association did not correlate with clinically established biomarkers of empathize with to protected checkpoint validate in other tumors.

The biomarker dissection unflinching that epithelial-mesenchymal evolving (EMT) gene airing, which is a cancer standing associated with a more bellicose biology, correlated with hostile suffering, treatment partisans and poorer comeback rates.

To delineate a tumor circumstances predictive of home-coming reciprocity to this hypnotic treatment, researchers examined pre-treatment untouched slack subsets using 15 to in the wink of an eye unshrinking samples. They establish that VEGF boundary-line improves the effectiveness of exempt checkpoint inhibitors alongside way of adapting the immunosuppressive tumor environment.

"I am uncommonly encouraged away the responses to this treatment, and I am anticipating that with additional scrutinization this last wishes as purvey a lead beyond treatment alternative against these patients," Raghav said. "I am obligated looking in locale of the patients who are well-disposed to participate in clinical trials and hike support our cognition of rare cancers."

Additional trials with larger numbers of patients are needed to validate these study results, abort if this drug parasynthesis could be abrogate as frontline treatment or renovate surgical outcomes for the benefit of these patients.

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